May 2026
Every article Wellness Radar published in May 2026 — long-form research, protocols, and reference work. Most-recent first.
Glutathione for Liver, Skin, and Fertility — What the Mechanism Actually Says
Glutathione is the liver's master detox cofactor. When Phase I and Phase II clearance work, the skin reads as healthier — not lighter. We map the liver-to-skin pathway, the fertility evidence, and the suppression conc…
Spermidine: The Autophagy Signal Your Fasting Depends On
A 2024 Nature Cell Biology paper showed spermidine is the required molecular intermediary for fasting and rapamycin to trigger autophagy. Here's what that means — and whether supplements can deliver it.
ApoB Explained: Why Your LDL Score Isn't the Full Picture
Standard cholesterol panels miss a critical number: ApoB, the protein coating every atherogenic particle. The 2026 ACC/AHA guidelines formally elevated it. Here's what it measures, who needs it, and what to do about it.
TRT and Knee Replacement: Large Study Flags 3 Serious Complication Risks
A 13,250-patient propensity-matched study from AAOS 2026 found TRT users had elevated pulmonary embolism, pneumonia, and acute kidney injury at 90 days after total knee arthroplasty — with periprosthetic joint infecti…
Microdose Lithium and the Brain: What the Harvard Alzheimer's Study Found
A 2025 Nature paper from Harvard found lithium is a naturally occurring neuroprotective mineral in the brain, depleted early in Alzheimer's — and that lithium orotate is the only form that avoids amyloid sequestration…
Nicotine and cognition: what the acetylcholine receptor data actually shows
Nicotine binds α4β2 and α7 nAChRs and reliably sharpens attention and working memory. But delivery method changes everything. A breakdown of pouches vs vapes vs cigarettes vs patches — and what the cognitive science a…
Enclomiphene + HCG for Testosterone Therapy: The Fertility-Preserving Alternative
Exogenous testosterone shuts down sperm production. Enclomiphene and HCG work upstream — raising endogenous T while keeping the HPG axis alive. Here's what the pharmacology and clinical trials actually show.
NAD+ Precursor Showdown: What the 2026 Clinical Data Actually Shows on NMN vs NR
First robust head-to-head human data on NMN vs NR. Both raise blood NAD+, but their downstream effects diverge. What the 2026 trials actually show — and where marketing has run ahead of tissue-level evidence.
Berberine vs Metformin: what the head-to-head data actually shows
Berberine and metformin share an AMPK mechanism and comparable HbA1c reductions in head-to-head trials. The differences are in lipid effects, GI tolerance, and what each one can't do.
Creatine for cognitive performance: the brain data beyond the gym
Creatine is not just a muscle supplement. Here is what the sleep-deprivation trials, vegetarian studies, and aging research actually show about creatine and brain function.
Gut microbiome and supplements: which microbes actually do something
Lactobacillus, Bifidobacterium, Akkermansia, spore-formers, and psychobiotics. What each does, what the evidence shows, and how to think about probiotic supplementation.
What Cold Plunges Actually Do to Your Cells: 2025 Evidence on Autophagy, Heat Shock Proteins, and Who Benefits Most
Cold water immersion drives real cellular effects — HSP upregulation, AMPK activation, autophagy induction. But the protocol matters enormously, and doing cold plunges after every strength session is working against y…
Lion's Mane mushroom for cognitive health: what the RCTs actually show
Lion's Mane (Hericium erinaceus) raises NGF and BDNF in preclinical models. Human RCTs show task-specific gains — not universal cognitive enhancement. Here's what the 2024–2025 data shows.
Glycine for sleep: the thermoregulatory mechanism and what the polysomnography data actually shows
Glycine lowers core body temperature before sleep onset — here is what the polysomnography trials show, the GeroScience systematic review, and a tiered dosing framework.
Reversing Immune Aging with Urolithin A: How a Pomegranate Metabolite Restores T Cell Function
Urolithin A drives mitophagy — the clearance of dysfunctional mitochondria. A 2025 Nature Aging study found it expands naive CD8+ T cells in middle-aged adults. Here's the mechanism, the data, and who benefits most.
Taurine and longevity: what the 2023 Science paper actually found
A single Science paper put taurine on the longevity map. Circulating taurine drops 67% from childhood to age 60. Here's what the data says — and what it doesn't yet prove in humans.
Magnesium for sleep: what the 2025 RCT data actually shows
The largest placebo-controlled trial of magnesium bisglycinate for sleep published in 2025.
Scientists Found a Way to Make Cells Burn More Calories — Without Damaging the Heart
University of Technology Sydney researchers published in Chemical Science a new class of mild mitochondrial uncouplers that raise cellular energy expenditure without the cardiovascular toxicity that killed DNP.