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State of evidence · Updated Jul 25, 2026

Sex & Hormones

TRT, enclomiphene, HCG, hormone-axis interventions.

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Jul 25, 2026Last update
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7 Moderate claims17 Emerging claims13 Weak claims10 Hype claims
Latest finding · Jul 25, 2026

Horny Goat Weed & Icariin: Natural Viagra?

The name is doing a lot of work, and so is the marketing. Horny goat weed — the herb Epimedium, a fixture of traditional Chinese medicine — is sold everywhere as a botanical alternative to Viagra, and unlike most aphrodisiac claims, this one has a real mole…

1 Emerging1 Weak1 Hype
2026
Jul 12, 2026

Boron for Testosterone: Does It Actually Work?

Boron is one of those ultra-trace minerals that supplement marketing loves precisely because almost nobody knows what it does. The pitch is confident: a few milligrams a day and testosterone climbs, estrogen falls, and your hormones snap into fighting shape.

3 Emerging1 Weak1 Hype
Jul 05, 2026

Fenugreek for Testosterone: Does It Work?

Fenugreek is one of the most heavily marketed “natural testosterone boosters” on the shelf, and the pitch is always the same: a humble kitchen herb that quietly raises your T.

1 Moderate2 Emerging1 Weak1 Hype
Jul 01, 2026

Black Cohosh: Does It Really Ease Hot Flashes?

Black cohosh is the best-selling herb for menopause — a buttercup-family root bottled and sold to cool hot flashes, quiet night sweats, and steady mood and sleep.

3 Emerging2 Weak
Jun 29, 2026

DIM Supplements: Do They Balance Your Hormones?

DIM is the compound your gut makes from broccoli and cabbage, bottled and sold to “detox estrogen,” balance hormones, clear stubborn acne, and tune a man’s testosterone-to-estrogen ratio.

1 Moderate1 Emerging3 Weak
Jun 20, 2026

Saw Palmetto for Hair and Prostate: A Natural DHT Blocker?

Saw palmetto is the herb aisle’s answer to finasteride — a cheap berry extract sold to shrink an enlarged prostate and to slow hair loss by blocking the same hormone. The mechanism is real but mild.

2 Moderate1 Emerging2 Weak
Jun 12, 2026

Maca for Libido: What the Evidence Actually Shows

Maca is sold as a natural libido-and-energy boost, and half the pitch is fair. Its best-supported claim — sexual desire — rests on a handful of small, low-quality trials that point the same direction.

2 Emerging1 Weak2 Hype
Jun 10, 2026

Zinc and Testosterone: Booster, or Just a Deficiency Fix?

Scroll men’s health TikTok long enough and zinc gets sold as a natural testosterone switch — pop the pill, watch your hormones climb. The truth is narrower and more useful than the hype.

2 Moderate1 Emerging1 Weak1 Hype
Jun 06, 2026

Seed Cycling for Hormones: Does It Actually Work?

Seed cycling is one of the most-shared hormone rituals on TikTok and Instagram: eat flax and pumpkin seeds for the first half of your cycle, switch to sesame and sunflower for the second, and your estrogen and progesterone supposedly fall into balance.

1 Moderate1 Emerging2 Hype
Jun 03, 2026

Fadogia Agrestis: Hype, Rat Studies, Real Risk

Few ingredients have ridden the testosterone-booster wave harder than Fadogia agrestis — a West African shrub now stacked into countless “natural T” capsules and marketed as a needle-free way to push your own hormones up.

2 Emerging1 Weak2 Hype
May 21, 2026

Plastics and Estrogen: The Hormonal Cost of Our Containers

BPA activates estrogen receptors at nanomolar concentrations. Phthalates suppress testosterone synthesis. The average person carries detectable levels of both in their urine right now. A 3-day dietary intervention drops BPA by 66%.

May 18, 2026

Why testosterone keeps falling — causes and what works

Four major longitudinal cohorts confirm it: testosterone levels in men are lower today than they were fifty years ago — independent of age, independent of BMI, independent of every lifestyle confounder researchers could control for. …

May 17, 2026

TRT and Knee Replacement: 3 Serious Risks

Data presented at AAOS 2026 from a propensity-matched analysis of 13,250 patients found that men on testosterone replacement therapy (TRT) face meaningfully higher rates of pulmonary embolism, pneumonia, and acute kidney injury in the 90 days after total kn…

May 15, 2026

Enclomiphene + HCG: Testosterone Without Killing Fertility

Exogenous testosterone works — but it shuts down the hypothalamic-pituitary-gonadal (HPG) axis and halts sperm production within weeks. Enclomiphene and human chorionic gonadotropin (HCG) attack the problem upstream.

May 09, 2026

Testosterone in Women: Energy, Mood & Cognition

A May 2026 observational study of 332 women aged 27–78 found individualized testosterone replacement produced significant improvements across energy, mood, and cognitive function. But the signals don't arrive together — and understanding the…

2025
Aug 31, 2025

Oral Testosterone 96% Restoration Rate — KYZATREX TRT Data

KYZATREX (testosterone undecanoate) is the first FDA-approved oral testosterone replacement therapy (TRT) for male hypogonadism. Clinical trial data shows it restores testosterone to the normal range in up to 96% of men — no injections, no gels, no pellets.